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and decreased the expression of caspase-3, inhibited apoptosis, and ultimately attenuated cisplatin-induced hair cell loss in the HEI-OC1 cell line ( Pomegranate extract (PE) is rich in polyphenols and exhibits strong antioxidant activity ( Anthocyanins is an extract of Vaccinium myrtillus, which presents antioxidant effects at high doses, thus reducing oxidative stress indices and preventing cell degeneration and protecting hearing from cisplatin-induced ototoxicity ( 4 Discussion The protective mechanism of polyphenols against cisplatin ototoxicity is mainly to build two major protective barriers in normal tissues

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